Selected
Publications

Research publications for reading.

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Databases
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Data from our publications.

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MitoSYSTEMS
Research Centre

Proteomics & Genomics Core Facility

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Welcome to the Babu Lab

The Babu Lab is located at the modern style Research and Innovation Centre, University of Regina, Saskatchewan.

Babu’s research brings in a blend of quantitative genetics, integrated genomics, systems proteomics and interactome network mapping to panoramically uncover the multiple facets of human disease and microbial infections. Our research interests span frontline topics of immediate health concerns, including neurobiology, mitochondrial biology and the ongoing threat of microbial resistance to frontline antibiotic treatments. The large-scale web of information we untangle from comprehensive networks of physical (protein-protein) and functional (gene-gene, or genetic) interaction maps offer holistic understanding of the molecular attributes of detrimental diseases, and how altered cellular bioprocesses result in disease onset and/or progression. Our broad range of expertise aims to integrate physical and functional interaction data to painstakingly identify higher order macromolecular protein complexes that control the inner workings of the cell and reveal pathway defects of pathological nature for targeted therapeutic interventions.

We strive to recruit talented scientists in areas such as computational biology, protein biochemistry, advanced molecular biology, structural biology and mass spectrometry to create and maintain a vibrant hub of scientific research that rapidly transforms our research findings into beneficial products that ameliorate patient health in Canada and the world at large.

publications

Featured Publications

PMID:32325033

BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain

Pourhaghighi, R., Ash, P.E.A., Phanse, S., Goebels, F., Hu, L.Z.M., Chen, S., Zhang, Y., Wierbowski, S.D., Boudeau, S., Moutaoufik, M.T., Malty, R.H., Malolepsza, E., Tsafou, K., Nathan, A., Cromar, G., Guo, H., Abdullatif, A.A., Apicco, D.J., Becker, L.A., Gitler, A.D., Pulst, S.M., Youssef, A., Hekman, R., Havugimana, P.C., White, C.A., Blum, B.C., Ratti, A., Bryant, C.D., Parkinson, J., Lage, K., Babu, M., Yu, H., Bader, G.D., Wolozin, B., Emili, A.

Cell Systems, Volume 10, Issue 4, 22 April 2020, Pages 333-350.e14

PMID:32325033